ABSTRACT
Background: Cutaneous horn is a clinical term used to describe a hard, keratotic conical lesion. Its base may be a papule, plaque or nodule
Objectives: An approach for how to diagnose and manage a cutaneous horn
Materials and methods: Here-in we report an aged male 85-years old presented with a history of painful slowly progressive skin lesion over his right foot 7 months ago
Results: The past medical history revealed that the lesion was preceded by presence of a cutaneous horn [CH] at the same site of the current skin lesion. That CH was persistent for a year before it spontaneously fell down. Skin biopsy from the base of the CH was taken at that time, it was consistent with underlying actinic keratosis. He did not receive any treatment for his CH. Currently skin examination revealed fungating ulcer measuring 6X6 cm on the dorsum of the right foot. There was no inguinal lymphadenopathy. Punch skin biopsy was taken from the edge of the ulcer for histopathological examination
Conclusion: On the basis of the above clinicopathological findings, a diagnosis of well differentiated Squamous Cell Carcinoma was made. The patient was referred to Oncologist for appropriate management
ABSTRACT
Background: Cutaneous horn is a clinical term used to describe a hard, keratotic conical lesion. Its base may be a papule, plaque or nodule
Objectives: An approach for how to diagnose and manage a cutaneous horn
Materials and methods: Here-in we report an aged male 85-years old presented with a history of painful slowly progressive skin lesion over his right foot 7 months ago
Results: The past medical history revealed that the lesion was preceded by presence of a cutaneous horn [CH] at the same site of the current skin lesion. That CH was persistent for a year before it spontaneously fell down. Skin biopsy from the base of the CH was taken at that time, it was consistent with underlying actinic keratosis. He did not receive any treatment for his CH . Currently skin examination revealed fungating ulcer measuring 6X6 cm on the dorsum of the right foot. There was no inguinal lymphadenopathy. Punch skin biopsy was taken from the edge of the ulcer for histo-pathological examination
Conclusion: On the basis of the above clinicopathological findings, a diagnosis of well differentiated Squamous Cell Carcinoma was made. The patient was referred to Oncologist for appropriate management
ABSTRACT
Background: two oral antifungal agents, griseofulvin and terbinafine, have regulatory approval but it is unknown whether one has superior overall efficacy. Genus-specific differences in efficacy are believed to exist for the two agents. It is not clear at what doses and durations of treatment these differences apply
Purpose: the purposes of this meta-analysis were to determine whether a statistically significant difference in efficacy exists between these agents at a given dose and duration of each in tinea capitis infections overall and to determine whether a genus-specific difference in efficacy exists for these two treatments at a given dose and duration of each. We performed a literature search for clinically and methodologically similar randomized controlled trials comparing 8 weeks of griseofulvin [6.25-12.5 mg?kg?day] to 4 weeks of terbinafine [3.125-6.25 mg?kg?day] in the treatment of tinea capitis. A meta-analysis was performed using the Mantel-Haenszel method and random effects model; results were expressed as odds ratios with 95%
Results: meta-analysis of randomized controlled trials did not show a significant difference in the overall efficacy of the two drugs at the doses specified, but specific efficacy differences were observed based on the infectious species. For tinea capitis caused by Microsporumspp., griseofulvin is superior [p = 0.04], whereas terbinafine is superior for Trichophyton spp. infection [p = 0.04]
Conclusion: our results support species-specific differences in treatment efficacy between griseofulvin and terbinafine and provide a clinical context in which this knowledge may be applied
ABSTRACT
Background: Tinea capitis is a superficial fungal infection that predominantly affects the pediatric population. The etiological factors vary from area to area, and the exact occurrence remains obscure. The clinicoepidemiological and mycological aspects of this dermatophytosis were studied in King Abdulaziz Hospital
Purpose: To determine the clinicoepidemiological aspects and mycological findings of dermatophytes involved in tinea capitis cases
Subjects and Methods: KOH examination, Wood's lamp examination, and fungal culture were performed in 50 clinically diagnosed cases of tinea capitis with patients' age up to 13 years over a period of 8 months. The epidemiological factors associated with the disease were also evaluated
Results: Tinea capitis was predominant in the 3-6 and 6-9 years age groups with a male preponderance. Grey patch tinea capitis was the most common variant. KOH positivity was 74%, and Trichophyton tonsurans was the most common fungal isolate
Conclusion: Tinea capitis is a very common fungal infection in our setting. Early detection and diagnosis is mandatory to prevent its spread in the community as well as the development of scarring alopecia in the affected individual